Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression
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چکیده
منابع مشابه
Effect of Vitamin D treatment on Interleukin-2 and Interleukin-4 Genes expression in Multiple Sclerosis
Introduction: Multiple sclerosis is a chronic inflammatory disease of central nervous system. The etiology of MS is slightly known, but genetic and environmental factors are reported. Vitamin D regulates gene expression and affects target cell functions. The aim of this study was to investigate the expression variation of IL-2 and IL-4 genes under vitamin D supplementation in patients with mult...
متن کاملInterleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes.
During systemic inflammation, the liver becomes unresponsive to growth hormone (GH), resulting in decreased plasma insulin-like growth factor-I (IGF-I) with concomitant reductions in lean body mass. Transgenic mice that overexpress IL-6 also demonstrate impaired growth and decreased IGF-I. To determine whether IL-6 directly inhibits GH-inducible gene expression, CWSV-1 hepatocytes were incubate...
متن کاملeffect of vitamin d treatment on interleukin-2 and interleukin-4 genes expression in multiple sclerosis
introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...
متن کاملThymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway.
The pathogenesis of pulmonary hypertension (PH) includes an inflammatory response. Thymulin, a zinc-dependent thymic hormone, has important immunobiological effects by inhibiting various proinflammatory cytokines and chemokines. We investigated morphological and hemodynamic effects of thymulin administration in a rat model of monocrotaline (MCT)-induced PH, as well as the pattern of proinflamma...
متن کاملExpression of interleukin-6 by intestinal enterocytes.
AIMS To investigate the cellular source of the cytokine interleukin-6 (IL-6) in the small and large intestines of patients with inflammatory bowel disease, coeliac disease, and in controls. METHODS IL-6 was detected in frozen sections of bowel by single and double label indirect immunofluorescence using rabbit polyclonal and murine monoclonal anti-IL-6 antibodies. The murine monoclonal antibo...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v78.8.2070.2070